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85 There is evidence that Hunner lesions are more common in IC/BPS patients of age over 50 years

In some embodiments, any formulation or composition described herein has a pH that allows for sterilization (e.g., by filtration or aseptic mixing or heat treatment and/or autoclaving (e.g., terminal sterilization)) of a formulation or composition without degradation of the therapeutic agent

Regarding zinc supplements and female fertility, a 2019 study has associated lower levels of zinc in the blood with a longer time to conception

The most frequently prescribed drugs reflect our most common chronic conditions: heart disease, high blood pressure, diabetes, thyroid disorders, respiratory illnesses, pain/inflammation, mental health issues, and infections

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Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The handling editor declared a past co-authorship with the authors